Press release
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22/05/2018: MElkin Pharmaceuticals welcomes the breakthrough achieved by its academic collaborators in the knowledge of depression, as well as the promising preclinical data of the PepElk compound in the treatment of depression. Dowload Press Release (pdf)…
Press article
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16/11/2017: La lettre d’innovation du CNRS – MElkin Pharmaceuticals : des molécules innovantes pour le traitement de certains cancers. La start-up MElkin Pharmaceuticals développe des peptides synthétiques issus des travaux de recherche menés au laboratoire Neuroscience Paris-Seine au sein de l’Institut Biologie Paris Seine. Read more…
Publications
- Antidepressive effects of targeting ELK-1 signal transduction. Apazoglou K, Farley S, Gorgievski V, Belzeaux R, Lopez JP, Grenier J, Ibrahim EC, El Khoury MA, Tse YC, Mongredien R, Barbé A, de Macedo CEA, Jaworski W, Bochereau A, Orrico A, Isingrini E, Guinaudie C, Mikasova L, Louis F, Gautron S, Groc L, Massaad C, Yildirim F, Vialou V, Dumas S, Marti F, Mechawar N, Morice E, Wong TP, Caboche J, Turecki G, Giros B, Tzavara ET. Nat Med. 2018
- Elk-1 a transcription factor with multiple facets in the brain. BesnardA, Galan-Rodriguez B, Vanhoutte P, Caboche J. Front Neurosci. 2011 Mar 16;5:35.
- Alterations of molecular and behavioral responses to cocaine by selective inhibition of Elk-1 phosphorylation. Besnard A, Bouveyron N, Kappes V, Pascoli V, Pagès C, Heck N, Vanhoutte P, Caboche J. J Neurosci. 2011 Oct 5;31(40):14296-307
- A TAT-DEF-Elk-1 peptide regulates the cytonuclear trafficking of Elk-1 and controls cytoskeleton dynamics. Lavaur J, Bernard F, Trifilieff P, Pascoli V, Kappes V, Pagès C, Vanhoutte P, Caboche J. J Neurosci. 2007 Dec 26;27(52):14448-58.
- Opposing roles of Elk-1 and its brain–specific isoform, short Elk-1, in nerve growth factor-induced PC12 differentiation. Vanhoutte P, Nissen JL, Brugg B, Gaspera BD, Besson MJ, Hipskind RA, Caboche J. J Biol Chem. 2001 Feb 16;276(7):5189-96.
- Delta 9-tetrahydrocannabinol–induced MAPK/ERK and Elk-1 activation in vivo depends on dopaminergic Valjent E, Pagès C, Rogard M, Besson MJ, Maldonado R, Caboche J. Eur J Neurosci. 2001 Jul;14(2):342-52.
- Involvement of the extracellular signal-regulated kinase cascade for cocaine–rewarding properties. ValjentE, Corvol JC, Pages C, Besson MJ, Maldonado R, Caboche J. J Neurosci. 2000 Dec 1;20(23):8701-9.
Patents
- Pepsignal Concept 2006 patent, Vanhoutte P, Caboche J. , WO 2006/08724
- Pepsignal and depression. 2010 paten, Caboche J, Tzavara E, Vanhoutte P, Giros B. , WO2010/037841
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A Selective inhibitor of c-Fos and their antiproliferative properties. 2014 Patent, Vanhoutte P, Caboche J. , WO201555218.
