Pepsignal® is a cell-penetrating small synthetic peptide containing a « bait » sequence corresponding to the docking domain of targeted protein onto activated ERK as exemplified here with PepFos.
This “Lead” compound (also called TAT-DEF-c-Fos) specifically blocks ERK/c-Fos protein-protein interaction (at the DEF Docking domain). In this way, the peptide inhibits c-Fos protein phosphorylation by ERK, thus impeding its cellular accumulation and blocking the associated excessive proliferation.

MElkin Pharmaceuticals