![](http://www.melkin-pharma.com/wp-content/uploads/2018/01/cells-1872666_1920-1-e1516627198530.jpg)
Pepsignal® is a cell-penetrating small synthetic peptide containing a « bait » sequence corresponding to the docking domain of targeted protein onto activated ERK as exemplified here with PepFos.
This “Lead” compound (also called TAT-DEF-c-Fos) specifically blocks ERK/c-Fos protein-protein interaction (at the DEF Docking domain). In this way, the peptide inhibits c-Fos protein phosphorylation by ERK, thus impeding its cellular accumulation and blocking the associated excessive proliferation.